Yes — and the difference matters for who is responsible. A driver-assist system, like Tesla's Autopilot or Full Self-Driving, automates parts of driving but still requires a human to supervise and take over. Because the human is expected to stay in control, the driver is generally still responsible for the vehicle.
A fully autonomous vehicle or robotaxi, by contrast, drives itself, and there may be no at-fault human driver at all. There, responsibility shifts toward the company operating the vehicle and the manufacturer. So the same crash can point to very different responsible parties depending on which kind of system was involved.
In both situations the maker can share responsibility if the system was defective or was marketed in a way that overstated its abilities. Sorting this out depends on the vehicle's data and expert analysis, which is why preserving that data early is so important.